USMLE Biochemistry Mnemonics

Nice mnemonic is for remembering what a southern, northern and western blot are; the mnem is "snowdrop"…
S…(Southern)………D….(DNA)
N…(Northern)……….R….(RNA)
OOOOOOOOOOOOOOOOOOOO
W…(Western)……….P….(Protein)

CADET for movement of the hemoglobin curve to the right
C = Increase in carbon dioxide
A = Acidosis (low ph)
D = Increase in 2.3,DPG
E- = Exercise
T = increase in temperature
So basically everything is increased except ph, which is low causing acidosis

* PDH
* Alpha-ketoglutarate dehydrogenase
* Branched-chain ketoacid dehydrogenase

all use " TLC (tender love and care) For Nancy"

Thiamine pyrophosphate, Lipoic Acid, Coenzyme A, FADH2, NADH

CIA sends soldiers from Michigan/Ontario

C-citrate
I-isocitrate
A-alph KG
S-succinyl COA
S-succinate
F-fumarate
M-malate
O-oxaloacetate

essential amino acids
PVT TIM HALL
Phenylalanine
Valine
Threonine
Tryptophan
Isoleucine
Methionine
Histidine
Arginine
Lysine
Leucine

Collared Central Intelligence Agent Spoke Slander For Money.

C-Citrate synthatase
C- Cis -aconitase
I- Isocitrate dehydrogenase
A-Alpha ketogluturate
S-Succinyl CoA thiokinase
S-Succinase
F- Fumarase
M-Malate Dehydrogenase

Any Help In Learning
These Little Molecules
Proves Truly Valuable!

Arginine, Histidine, Isoleucine, Leucine,
Threonine, Lysine, Methionine,
Phenylalanine, Tryptophan, Valine

PVT TIM HALL : The 10 essential amino acids

P= Phenylalanine
V= Valine
T=Threonine
T=Tryptophan
I=Isoleucine
H=Histidine
A=Arginine
L=Leucine
L=Lysine

ToMYs GirlFrind is AHa!!

TRINUCLEOTIDE REPEAT DISORDERS:
everywhere it is repeat of C__G , where __ stands for:

T(CTG) : in Myotonia dystrophica

G(CGG): in FRagile x syndrome

A(CAG) : Hungtons chorea and other disorder

Do Enter After the Bell

Cyclin D/E - G1 S
Cyclin A - S G2
Cyclin B - G2 M

Learning the Cofactors for Enzymes is Painful so you hit them with a BAP!
BAP! Tender Loving Care for Noone!

(BAP needs TLCFN)

Branched Chain Ketoacid DH
Alpha ketoglutarage DH
PDH
(by the way, all are DH enzymes; ALL DH enzymes produce NADH)

they need:

TTP from Thiamine (B1)
Lipoic Acid (Synthesized; not from a vitamin)
CoA (from Pantothenate)
FAD(H2) from Riboflavin (B2)
NAD(H) from Niacin (B3)

To remember what TLCFN comes from its: BSPRN (bull sh.. prn)

Another one:

Carboxylases need ABC:
ATP, Biotin, CO2

All Dehydrogenases: make NADH

All Kinases: Phosphorylate (KINdly put a phosphate on)

All Phosphatases: DEphosphorylate (PhosphaTASE, TAKES off Phosphate)

Glucagon puts Phosphate ON (phosphorylates); and INversely INsulin does the opposite (dephosphorylate)

This is a good way to remember what enzymes of which pathways are active/inactive in phosphorylated/dephosphorylated form

eg. Insulin activates Glycolysis, and Glycogen synthesis, so the enzymes that it activates in those pathways will be active in DEphosphorylated form.

and: Glucagon activates Glycogenolysis and Gluconeogenesis, so the enzymes that it activates in those pathways will be active in Phosphorylated form.

eukaryotic RNA polymerase

RNA polymerase III–>tRNA

Three goes with T

mRNA–> choose m for Middle number

so RNA poly II–> mRNA

RNA poly ONE is the Real ONE

poly I–> rRNA

essential amino acid

PuT HIM All on TV

P: phenylalanine
T: Threonine
H: histidine
I: Isoleucine
M: methionine

A:argine
L:lysine
L:Leccine
T: tryptophan
V : valine

FABRY’S
Foam cells found in glomeruli and tubules
Angiokeratomas/ Alfa galactosidase A deficiency
Burning pain in extremeties/ BUN elevated
Renal failure
YX (males, x linked recessive)
Sphingolipidosis

Elevated BUN: ABCD
Azotemia
Bleeding
Catabolic status
Diet (too much protein via IV)

Urea cycle intermediates:

Ordinarily, Careless Crappers Are Also Frivolous About Urination

Ornithine

Citrulline

Aspartate (enters the cycle)

Argininosuccinate

Fumarate (leaves the cycle)

Arginine

Urea (leaves the cycle)

-from FA-